Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

Main Article Content

Nasser Mohammed Hosny
Lamiaa A. A. Barakat

Abstract

Since the discovery of the platinum based complex, cisplatin, medicinal inorganic chemistry has attracted much more attention and a large number of platinum complexes with promising pharmacological properties have been synthesized. In this work a new platinum complex of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide (HL) has been synthesized and characterized by physical and spectral techniques, as elemental analysis, IR, EI-MS, 1H-NMR, thermal analysis, transmittance electron microscope (TEM) and magnetic moment. The results indicated that the ligand binds to Pt(II) in the enol form. Square-planar stereochemistry was suggested for the Pt(II) complex. The morphological characterization showed nano-sized spherical particles with average size 92 nm of the isolated complex. The synthesized Pt(II) complex exhibited a significant cytotoxic activity against HCT116 and HEPG2. Also in vivo study of the Pt(II) complex showed cytotoxic activity towards Ehrlich ascites carcinoma (EAC).

Keywords:
Synthesis, Pt(II) complex, cytotoxic activity

Article Details

How to Cite
Hosny, N., & Barakat, L. (2019). Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex. Asian Journal of Research in Biochemistry, 4(3), 1-12. https://doi.org/10.9734/ajrb/2019/v4i330070
Section
Original Research Article

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