Main Article Content
Background: African locust bean is a condiment believed to be for the people of low class. Its health importance has not been fully known especially to the so-called high class.
Aim: This study is aimed at investigating the effect of African locust bean on fasting blood sugar and lipid profile of albino rats.
Methods: African locust bean (ALB) was purchased from a local market at Orita-Challenge area of Ibadan, Nigeria. They were sun dried and milled into powder using an electronic blender. The powder was extracted with n-hexane (40–60°C) in a soxlet extractor for 18 hours. The defatted, dried marc was repacked and then extracted with methanol. The dried marc was extracted with methanol in the soxlet apparatus for 10 hours. The methanol solution was subsequently concentrated in a rotatory evaporator at 40°C. Ten adult male albino rats with body weight between 100 and 120 g were purchased from the Animal Holding Unit of the Department of Physiology, University of Ibadan, Nigeria. They were allowed 7 days acclimatization period and were divided randomly into 2 groups of five rats each. Animals in group 1 were administered normal saline solution while those in group 2 were administered extract of African locust bean. The animals were exposed to the African Locust Bean and saline solution at a dose of 3 ml per 100 g body weight 12 hourly via oral route of administration. After fourteen days of administration, the animals were fasted overnight and anaesthetized using diethyl ether. Blood samples were collected by cardiac puncture.
Results: ALB was observed to significantly lower fasting blood sugar, total cholesterol and triglyceride but increased HDL-cholesterol significantly when compared to those of the control group at p<0.05. LDL-cholesterol was not significantly different when animals treated with ALB were compared with those of the control group.
Conclusion: Increased blood sugar and hyperlipidemia has been implicated in diabetes. Cholesterolgenesis is a major onset of atherosclerosis and subsequent cardiovascular diseases. Therefore, ALB can serve as prophylaxis and remedies for several diseases caused by hyperglycemia and hyperlipidemia such as diabetes and coronary heart disease.
Furniss BS, Hannaford AJ, Rogers V, Smith PWG, Tatchell AJ. Vogel’s textbook of practical organic chemistry, 4th Edition. Longman, Britain. 1978;100-222,931-1152.
Subramaniam S, Fahy E, Gupta S, Sud M, Byrnes RW, Cotter D, Dinasarapu AR, Maurya MR. Chemical Reviews. 2011;111(10):6452–6490.
Fahy E, Subramaniam S, Murphy R, Nishijima M, Raetz C, Shimizu T, Spener F, Van Meer G., Wakelam M, Dennis EA. Journal of Lipid Research. 2009; 50(Supplement):S9–S14.
Page RA, Okada S, Harwood JL. Acetyl-CoA carboxylase exerts strong flux control over lipid synthesis in plants. Biochim. Biophys. Acta. 1994;1210:369-372.
Small DM. The physical chemistry of lipids. Handbook of Lipid Research. D. J. Hanahan, Editor. Plenum Press, New York. 1986;4.
Michelle A, Hopkins J, McLaughlin CW, Johnson S, Warner MQ, LaHart D, Wright JD. Human biology and health. Englewood Cliffs, New Jersey, USA: Prentice Hall; 1993.
Airaodion AI, Adejumo PR, Njoku CO, Ogbuagu, EO, Ogbuagu U. Implication of sugar intake in haemorrhoid and menstruation. International Journal of Research and Reports in Hematology. 2019;2(2):1-9.
Airaodion AI, Ogbuagu U, Ogbuagu EO, Oloruntoba AP, Agunbiade AP, Airaodion EO, Mokelu IP, Ekeh SC. Mechanisms for controlling the synthesis of lipids. International Journal of Research. 2019;6(2):123-135.
Odetola AA, Akinloye O, Egunjobi C, Adekunle WA, Ayoola AO. Possible antidiabetic and antihyperlipidaemic effect of fermented Parkia biglobosa (Jacq) extract in alloxan-induced diabetic rats. Clinical and Experimental Pharmacology and Physiology. 2006;33:808–812.
Owoade AO, Adetutu A, Airaodion AI, Ogundipe OO. Toxicological assessment of the methanolic leaf extract of Bridelia ferrugelia. The Journal of Phyto-pharmacology. 2018;7(5):419-424.
Owoade AO, Airaodion AI, Adetutu A, Akinyomi OD. Levofloxacin-induced dyslipidemia in male albino rats. Asian Journal of Pharmacy and Pharmacology. 2018;4(5):620-629.
World Health Organization. Archived from the original on 31 March 2014.
Rippe RS, Irwin JM, Eds. Manual of intensive care medicine (5th Ed.). Wolters Kluwer Health/Lippincott Williams & Wilkins. 2010;549. ISBN: 978-0-7817-9992-8.
Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009;32(7):1335–43.
Shoback DG, Gardner D, Eds. "Chapter 17". Greenspan's Basic & Clinical Endocrinology (9th Ed.). New York: McGraw-Hill Medical; 2011. ISBN: 978-0-07-162243-1.
Bierman EL, Ameral JAP, Balknap BH. Hyperlipidemia and diabetes mellitus. Diabetes. 1975;25:509–15.
Jackson JE, Bressler R. Clinical pharmacology of sulphonylurea as hypoglycemic agent: Part I. Drugs. 1981;22:211–45.
Prince P, Stanely M, Menon PV, Pari L. Hypoglycaemic activity of Syzigium cumini seeds: Effect on lipid peroxidation in alloxan diabetic rats. J. Enthopharmacol. 1998;61:1–7.
Venkateswaran S, Pari L, Saravenan G. Effect of Phaseolus vulgaris on circulatory antioxidants and lipids in streptozotocin-induced diabetic rats. J. Med. Food. 2002;5:97–104.
Latha M, Pari L. Preventive effects of Cassia auriculata L. flowers on brain lipid peroxidation in rats treated with streptozotocin. Mol. Cell. Biochem. 2003;243:23–8.
Loew S, Kaszkin M. Approaching the problem of bioequivalence of herbal medicinal products. Phytother. Res. 2002;16:705–11.
Ajaiyeoba EO. Phytochemical and antibacterial properties of Parkia biglobosa and Parkia biolor leaf extract. Aghil J. Biomed. Res. 2000;5:125–129.
Loci AS, Shaabha M, Khazraji AL, Husain A, Twaija A. Hypoglycemic effect of a valuable extract on some blood parameters in diabetic animals. J. Ethnopharmacol. 1994;43:167–171.
Ahardh CD, Bjorgell P, Nilson EP. The effect of tolnetamide in lipoproteins and lipoprotein lipase and hormone sensitive lipase. Diabetes Res. Clin. Pract. 1999;46: 99–108.
Frayn KN. Insulin resistance and lipid metabolism. Curr. Opin. Lipidol. 1993;4: 197–204.
Bopanna KN, Kannan J, Suchma G, Balaraman R, Ranthod SP. Antidiabetic and antihyperlipidemic effect of neem seed, kernel powder on alloxan diabetic rabbits. Ind. J. Pharmacol. 1997;29:162–7.
Rotimi OS, David AO, Olusola AT, Regina NU, Elizabeth AB, Oladipo A. Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues. Lipids in Health and Disease. 2015;14:13-30.
Bhattaram VA, Cercefe M, Cohlest C, Vest M, Deundo FH. Pharmacokinetics bioavailability herbal medicinal products. Phytomedicine. 2002;9:1–36.
Airaodion AI, Ogbuagu U, Ogbuagu EO, Airaodion EO, Agunbiade AP, Oloruntoba AP, Mokelu IP, Ekeh SC. Investigation of aqueous extract of Zingiber officinale root potential in the prevention of peptic ulcer in albino rats. International Journal of Research and Innovation in Applied Science. 2019;4(2):64-67.
Airaodion AI, Obajimi OO, Ezebuiro CN, Ogbuagu U, Agunbiade AP, Oloruntoba AP, Akinmolayan JD, Adeniji AR, Airaodion EO. Prophylactic efficacy of aqueous extract of Curcuma longa against indomethacin-induced ulcer. International Journal of Research. 2019;6(1):87-91.
Airaodion AI, Olayeri IM, Ewa AO, Ogbuagu EO, Ogbuagu U, Akinmolayan JD, Agunbiade AP, Oloruntoba AP, Airaodion EO, Adeniji AR, Obajimi OO, Awosanya OO. Evaluation of Moringa oleifera leaf potential in the prevention of peptic ulcer in wistar rats. International Journal of Research. 2019;6(2):579-584.
Saravanan R, Pari L. Antihyperlipidemic and antiperoxidative effect of diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. BMC Complement. Alternative Med. 2005;5:14–34.
Gordon DJ, Rifkind BM. High-density lipoprotein: The clinical implications of recent studies. New England Journal of Medicine. 1989;321(19):1311-1316.
Sviridiv D. Intracellular cholesterol trafficking. Histology and Histopathology. 1999;14:305-319.
Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM. The Yin and Yang of oxidation in the development of thefatty streak. A review based on the George Lyman DuffMemorial Lecture. Arteriosclerosis and Thrombosis in Vascular Biology. 1994;16:831-842.
Oram JF, Lawn RM. ABCA1: The gatekeeper for eliminating excess tissue cholesterol. Journal Lipid Research. 2001;42:1173-1179.
Law MR. Lowering heart disease risk with cholesterol reduction: Evidence from observational studies and clinical trials. European Heart Journal. 1999;1:S3-S8.
Stein O, Stein Y. Atheroprotective mechanisms of HDL- Atherosclerosis. 1999;144:285-303.
Das DK. Cardioprotection with high density lipoproteins. Fact or friction? Circulation Research. 2003;92:258-260.
Castelli L. Epidemiology of coronary heart disease. Am. J. Med. 1984;76:4–12.
Most read articles by the same author(s)
- Augustine I. Airaodion, Olaide O. Awosanya, Emmanuel O. Ogbuagu, Uloaku Ogbuagu, Onyinyechi C. Njoku, Chimdi Esonu, Edith O. Airaodion, Assessment of Bread in Ogbomoso Metropolis for the Presence of Potassium Bromate , Asian Journal of Research in Biochemistry: 2019 - Volume 4 [Issue 2]