In-vivo Study on Organometallic Compounds as Anticancer Agents

Main Article Content

F. Z. Mohammed
Elsherbiny H. Elsayed
Atef E. Abd Elbaky
H. M. Shalaby

Abstract

This study aims to study the in-vivo anticancer effect of the synthesized copper complexes of 2,3-dihydroxy benzaldehyde thiosemicarbazone (3a,b), followed by evaluating their antioxidant activity.  Materials and methods: A total number of 80 adult female swiss albino mice weighing 20-25 gm were divided into 8 groups (10 mice /each group).  The acute toxicity was estimated by intraperitoneal injection of the compounds (3a, b). Results:  We found that, 5 mg /kg and 10 mg /kg were considered to be the most effective dose of compounds 3a & 3b, respectively. The mean volume of EAC in the positive control group was found to be 4.2 ±0.5 (mL), this value was significantly decreased by 100%, (p<0.001) for 3a & 3b treated groups, respectively.

Keywords:
Anticancer, copper complexes, 2,3-dihydroxy benzaldehyde thiosemicarbazone, Erhlich Ascites Carcinoma (EAC), swiss albino mice.

Article Details

How to Cite
Mohammed, F. Z., Elsayed, E. H., Elbaky, A. E. A., & Shalaby, H. M. (2019). In-vivo Study on Organometallic Compounds as Anticancer Agents. Asian Journal of Research in Biochemistry, 5(1), 1-8. https://doi.org/10.9734/ajrb/2019/v5i130082
Section
Original Research Article

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