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This study evaluated the Hematotoxic effect of water soluble fraction (WSF) of Bonny Light Crude Oil (BLCO) in Wistar Albino rats. After preparation of the WSF and a range finding test, the Wistar albino rats were administered three concentrations (25%, 50% and 100%) of WSF of BLCO for 30 and 60days. Data from the study showed that there was a significant decrease (p≤0.05) in PCV values (30.2% in the control group to 17.2% in the 100% group), Hb levels decreased significantly from 9.25 g/dl in the control group to 5.27 g/dl in the 100% group. WBC count decreased significantly from 2932 mm3 in the control group to 136 mm3 in the 100% group and finally RBC count decreased significantly from 241.8E4 mm3 to 567 mm3 with increasing concentrations in the treatment groups after 60days administration. These results suggest that the oral consumption of the WSF of BLCO led to an onset of anaemia which indicates the presence of less than normal concentrations of PCV, Hb and RBC.
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