Vitamin D, Calcium and Phosphorus Status Involvement during COVID-19 Infection

Abdalla Eltoum Ali *

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Alzaeim Alazhari, Sudan and Program of Medicine & Medical Laboratory Science, Alofoug College of Science & Technology, Khartoum, Sudan.

Mohamed Fathy Seyyed Ahmed

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Alzaeim Alazhari, Sudan.

Somia Mohammed Suliman

Program of Medicine & Medical Laboratory Science, Alofoug College of Science & Technology, Khartoum, Sudan.

Ibrahim Ahamed Ali Karti

Program of Medicine & Medical Laboratory Science, Alofoug College of Science & Technology, Khartoum, Sudan.

Haidar Eltayeb Saleh

Clinical Research Laboratory Services, Sylvester Comprehensive Cancer Center (SCCC), Miami University, Miami Fl33136, USA.

*Author to whom correspondence should be addressed.


Background: COVID-19 is associated with a weak immune system in the human body. Vitamin D plays a role in the body’s immune system and is known to enhance the function of immune cells. In this case, vitamin D inhibits some of the inflammation that can make COVID-19 more severe. The is study aims to determine the serum levels of vitamin D, calcium, and phosphorus in COVID-19 patients.

Methods: This was a cross sectional study conducted during the period from January 2021 to July 2021. 50 COVID-19 patients as a case study and 50 healthy individuals as a control group were included in this study. Blood samples were collected from the study group and measured for vitamin D using Enzyme-linked immunosorbent assay (ELISA) technique. Calcium and phosphate were measured by the Cobas 6000 fully automated analyzer (Roche, Germany).

Results:  The study result showed that in COVID-19 patients, vitamin D (27 ± 5 ng/mL), p-value = 0.000, and calcium (10.2 ± 4 mg/dL), p-value = 0.000, in comparison with control. There was a correlation between vitamin D (r = -.771; p =.000) and calcium (r = -.752; p =.000) and the severity of disease.

Conclusions: According to our research, vitamin D deficiency may increase the risk of developing COVID-19 and the risk of developing severe illnesses.

Keywords: COVID -19, vitamin D, calcium, phosphate

How to Cite

Ali, A. E., Ahmed, M. F. S., Suliman, S. M., Karti, I. A. A., & Saleh, H. E. (2022). Vitamin D, Calcium and Phosphorus Status Involvement during COVID-19 Infection. Asian Journal of Research in Biochemistry, 11(2), 29–38.


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