Vitamin D, Calcium and Phosphorus Status Involvement during COVID-19 Infection

Abdalla Eltoum Ali *

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Alzaeim Alazhari, Sudan and Program of Medicine & Medical Laboratory Science, Alofoug College of Science & Technology, Khartoum, Sudan.

Mohamed Fathy Seyyed Ahmed

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Alzaeim Alazhari, Sudan.

Somia Mohammed Suliman

Program of Medicine & Medical Laboratory Science, Alofoug College of Science & Technology, Khartoum, Sudan.

Ibrahim Ahamed Ali Karti

Program of Medicine & Medical Laboratory Science, Alofoug College of Science & Technology, Khartoum, Sudan.

Haidar Eltayeb Saleh

Clinical Research Laboratory Services, Sylvester Comprehensive Cancer Center (SCCC), Miami University, Miami Fl33136, USA.

*Author to whom correspondence should be addressed.


Abstract

Background: COVID-19 is associated with a weak immune system in the human body. Vitamin D plays a role in the body’s immune system and is known to enhance the function of immune cells. In this case, vitamin D inhibits some of the inflammation that can make COVID-19 more severe. The is study aims to determine the serum levels of vitamin D, calcium, and phosphorus in COVID-19 patients.

Methods: This was a cross sectional study conducted during the period from January 2021 to July 2021. 50 COVID-19 patients as a case study and 50 healthy individuals as a control group were included in this study. Blood samples were collected from the study group and measured for vitamin D using Enzyme-linked immunosorbent assay (ELISA) technique. Calcium and phosphate were measured by the Cobas 6000 fully automated analyzer (Roche, Germany).

Results:  The study result showed that in COVID-19 patients, vitamin D (27 ± 5 ng/mL), p-value = 0.000, and calcium (10.2 ± 4 mg/dL), p-value = 0.000, in comparison with control. There was a correlation between vitamin D (r = -.771; p =.000) and calcium (r = -.752; p =.000) and the severity of disease.

Conclusions: According to our research, vitamin D deficiency may increase the risk of developing COVID-19 and the risk of developing severe illnesses.

Keywords: COVID -19, vitamin D, calcium, phosphate


How to Cite

Ali, Abdalla Eltoum, Mohamed Fathy Seyyed Ahmed, Somia Mohammed Suliman, Ibrahim Ahamed Ali Karti, and Haidar Eltayeb Saleh. 2022. “Vitamin D, Calcium and Phosphorus Status Involvement During COVID-19 Infection”. Asian Journal of Research in Biochemistry 11 (2):29-38. https://doi.org/10.9734/ajrb/2022/v11i2214.