Effect of Siphonochilus aethiopicus Methanolic Extract on Oxidative Stress Markers, Biochemical and Hematological Parameters in Experimentally Induced Arthritis Model in Mice

Elizé Dadaya *

Department of Life Sciences, Higher Teachers Training College, University of Bertoua, P.O Box 652, Bertoua, Cameroon.

Jeweldai Vedekoi

Department of Biotechnology and Pharmacognosy, Faculty of Science, University of Ebolowa, P.O. Box 118, Ebolowa, Cameroon.

Tchoubou Zacharie

Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814 Maroua, Cameroon.

Hervé Ngatanko Abaissou

Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814 Maroua, Cameroon.

Ndjonka Dieudonné

Department of Biological Sciences, Faculty of Science, University of Garoua, P.O. Box 346, Garoua, Cameroon.

*Author to whom correspondence should be addressed.


Abstract

Background: Siphonochilus aethiopicus belongs to the Zingiberaceae family. In Chinese medicine, Zingiberaceae are acknowledged for their anti-inflammatory and antioxidant properties, which contribute to immune system reinforcement. They are known to promote digestion, alleviate nausea, motion sickness and are involved incombating flu and cold. The current study was conducted to investigate the antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus (MESA).

Methodology: The in vivo study examined the anti-inflammatory impact of the extract (75, 150, and 300 mg/kg) using a formaldehyde-induced inflammation mouse model. The anti-arthritic effect of the MESA was determined by measuring paw diameter, body weight, biochemical parameters (C-reactive protein and rheumatoid factor) including oxidative stress markers (malondialdehyde, superoxide dismutase, catalase, and nitric oxide), and hematological parameters. Additionally, a histopathological examination was conducted to evaluate the outcome of treatment on tissue integrity.

Results: Results obtained show that the MESA significantly decreased paw inflammation (P < 0.05 to P < 0.001) and enhanced hematological and biochemical parameters. Additionally, MESA significantly ameliorated oxidative stress parameters (P < 0.05 to P < 0.001).

Conclusion: This finding suggests that Siphonochilus aethiopicus possesses strong antioxidant and anti-arthritic activity, supporting its traditional application as a remedy for rheumatoid arthritis.

Keywords: Antioxidant activities, anti-arthritic, anti-inflammatory, Siphonochilus aethiopicus


How to Cite

Dadaya , Elizé, Jeweldai Vedekoi, Tchoubou Zacharie, Hervé Ngatanko Abaissou, and Ndjonka Dieudonné. 2024. “Effect of Siphonochilus Aethiopicus Methanolic Extract on Oxidative Stress Markers, Biochemical and Hematological Parameters in Experimentally Induced Arthritis Model in Mice”. Asian Journal of Research in Biochemistry 14 (4):34-48. https://doi.org/10.9734/ajrb/2024/v14i4292.

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