Study of the Potential Role of Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels in the Diagnosis and Prognosis of Breast Cancer in Egyptian Females "A Case-Control Study"
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Published
Jul 18, 2020
Page:
1-8
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F. Z. Mohammed
Department of Biochemistry, Faculty of Science, Zagazig University, Egypt.
Lamis Gamal
Department of Chemistry-Biochemistry, Faculty of Science, Port Said University, Egypt.
Mohamed Farouk Mosa
Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Egypt.
I. M. El- deen
Department of Organic Chemistry, Faculty of Science, Port Said University, Egypt.
Abstract
Background: Breast cancer (BC) is the most common cause of malignancy in females all over the world. Continuous scientific research for the discovery of new markers helping is a cornerstone for early disease detection and proper management.
Aim of the Study: This study aimed to evaluate the role of Neutrophil gelatinase-associated lipocalin (NGAL) as prognostic markers for breast cancer in an Egyptian female population.
Patients and Methods: 120 BC patients and 30 healthy controls were the subjects of the study; serum NGAL levels were investigated and correlated with the clinicopathologic characteristics of the BC patients.
Results: Our study showed that NGAL was significantly different between healthy controls and BC patients, and it revealed a gradual increase with disease severity.
Conclusion: Our findings suggested that NGAL could be diagnostic marker for early case detection, and was shown to be associated with breast cancer prognosis, supporting its role as prognostic biomarker.
Keywords:
Breast cancer, NGAL, diagnosis, prognosis
Article Details
How to Cite
Mohammed, F. Z., Gamal, L., Mosa, M. F., & deen, I. M. E.-. (2020). Study of the Potential Role of Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels in the Diagnosis and Prognosis of Breast Cancer in Egyptian Females "A Case-Control Study". Asian Journal of Research in Biochemistry, 7(1), 1-8. https://doi.org/10.9734/ajrb/2020/v7i130128
Section
Original Research Article
References
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Garner J. In the case of breast cancer, how can these be combined to give prognostic information? Questions for the MRCS vivas. 2004; London: Arnold; 231.
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Fryczkowski M, Bułdak J, Hejmo T, Kukla M, Żwirska-Korczala K. Circulating levels of NGAL, leptin, VEGF, and HGF and their clinical relevance with PSA marker in prostate cancer. Disease Markers. 2018; 3852401:9-21.
Kim Y, Seok JY, Hyun KY, Lee GH, Choi SC. Correlation of glasgowpronostic score or procalcitonin to clinical variables in patients with pretreatment lung cancer. Biomedical Science Letter. 2016;22:9-17.
Kurozumi S, Alsaeed S, Orah N. Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer. Breast Cancer Res Treat. 2020; 179:557-564.
Soni SS, Ronco C, Katz N, Cruz DN. Early diagnosis of acute kidney injury: The promise of novel biomarkers. Blood Purif. 2009;28(3):165-174.
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Roli L, Pecoraro V, Trenti T. Can NGAL be employed as prognostic and diagnostic biomarker in human cancers? A systematic review of current evidence. The International Journal of Biological Markers. 2017;32(1):53–61.
Wu Y, Sarkissyan M, Vadgama JV. Epithelial-mesenchymal transition and breast cancer. J Clin Med. 2016;5:E13.
Masuda H, Baggerly KA, Wang Y. Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes. Clin Cancer Res. 2013;19:5533–5540.
Wang YP, Yu GR, Lee MJ. Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/ Lcn2/Twist1 pathway. Hepatology. 2013;58:1349-1361.
Leung L, Radulovich N, Zhu CQ. Lipocalin2 promotes invasion, tumorigenicity and gemcitabine resistance in pancreatic ductal adenocarcinoma. PLoS One. 2012;7(10):e46677.
Feng M, Feng J, Chen W. Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-κB-dependent activation of snail and epithelial mesenchymal transition. Mol Cancer. 2016;15:77.
Leng X, Ding T, Lin H. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res. 2009;69:8579-8584.
Wang YU, Zeng T. Neutrophil gelatinase associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta analysis. Biomedical Reports. 2013;1:479-483.
Provatopoulou X, Gounaris A, Kalogera E, Zagouri F, Flessas I, Goussetis E, Nonni A, Papassotiriou I,Zografos G. Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their complex MMP-9/NGAL in breast cancer disease. BMC Cancer. 2009;9(390).
Yang J, Bielenberg DR, Rodig SJ, Doiron R, Clifton MC, Kung AL, Strong RK, Zurakowski D, Moases MA.Lipocalin 2 promotes breast cancer progression. PNAS. 2009;106:3913-8.
Candido S, Maestro R, Polesel J, Catania A, Maira F, Signorelli S, McCubrey J, Libra M. Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer. Oncotarget. 2014;5(6).
Bauer M, Eickhoff JC, Gould MN, Mundhenke C, Maass N, Friedl A. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat. 2008;108(3):389-397.
Li SH, Hawthorne VS, Neal CL, Sanghera S, Xu J, Yang J, Guo H, Steeg PS, Yu D. Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation. Cancer Res. 2009;69:9163-8.
Nicolini A, Carpi A, Ferrari P, Rossi G. Immunotherapy prolongs the serum CEA-TPA-CA15.3 lead time at the metastatic progression in endocrine-dependent breast cancer patients: A retrospective longitudinal study. Cancer Lett. 2008;263: 122-129.
Flower DR. The lipocalin protein family: Structure and function. Biochem J. 1996; 318(1):1-14.
Wang YU, Zeng T. Neutrophil gelatinase associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta analysis. Biomedical Reports. 2013;1:479-483.
Garner J. In the case of breast cancer, how can these be combined to give prognostic information? Questions for the MRCS vivas. 2004; London: Arnold; 231.
Abdel-Aziz T, Azab N, Emara N, Odah M, El-deen IM. Study of BRCA2 gene mutations in egyptian females with breast cancer. International Journal of Innovative Research in Science. 2015;4(2):283-288.
Fryczkowski M, Bułdak J, Hejmo T, Kukla M, Żwirska-Korczala K. Circulating levels of NGAL, leptin, VEGF, and HGF and their clinical relevance with PSA marker in prostate cancer. Disease Markers. 2018; 3852401:9-21.
Kim Y, Seok JY, Hyun KY, Lee GH, Choi SC. Correlation of glasgowpronostic score or procalcitonin to clinical variables in patients with pretreatment lung cancer. Biomedical Science Letter. 2016;22:9-17.
Kurozumi S, Alsaeed S, Orah N. Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer. Breast Cancer Res Treat. 2020; 179:557-564.
Soni SS, Ronco C, Katz N, Cruz DN. Early diagnosis of acute kidney injury: The promise of novel biomarkers. Blood Purif. 2009;28(3):165-174.
Devarajan P. Review: Neutrophil gelatinase-associated lipocalin: A troponin-like biomarker for human acute kidney injury. Nephrology (Carlton). 2010;15(4): 419-428.
Roli L, Pecoraro V, Trenti T. Can NGAL be employed as prognostic and diagnostic biomarker in human cancers? A systematic review of current evidence. The International Journal of Biological Markers. 2017;32(1):53–61.
Wu Y, Sarkissyan M, Vadgama JV. Epithelial-mesenchymal transition and breast cancer. J Clin Med. 2016;5:E13.
Masuda H, Baggerly KA, Wang Y. Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes. Clin Cancer Res. 2013;19:5533–5540.
Wang YP, Yu GR, Lee MJ. Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/ Lcn2/Twist1 pathway. Hepatology. 2013;58:1349-1361.
Leung L, Radulovich N, Zhu CQ. Lipocalin2 promotes invasion, tumorigenicity and gemcitabine resistance in pancreatic ductal adenocarcinoma. PLoS One. 2012;7(10):e46677.
Feng M, Feng J, Chen W. Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-κB-dependent activation of snail and epithelial mesenchymal transition. Mol Cancer. 2016;15:77.
Leng X, Ding T, Lin H. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res. 2009;69:8579-8584.
Wang YU, Zeng T. Neutrophil gelatinase associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta analysis. Biomedical Reports. 2013;1:479-483.
Provatopoulou X, Gounaris A, Kalogera E, Zagouri F, Flessas I, Goussetis E, Nonni A, Papassotiriou I,Zografos G. Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their complex MMP-9/NGAL in breast cancer disease. BMC Cancer. 2009;9(390).
Yang J, Bielenberg DR, Rodig SJ, Doiron R, Clifton MC, Kung AL, Strong RK, Zurakowski D, Moases MA.Lipocalin 2 promotes breast cancer progression. PNAS. 2009;106:3913-8.
Candido S, Maestro R, Polesel J, Catania A, Maira F, Signorelli S, McCubrey J, Libra M. Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer. Oncotarget. 2014;5(6).
Bauer M, Eickhoff JC, Gould MN, Mundhenke C, Maass N, Friedl A. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat. 2008;108(3):389-397.
Li SH, Hawthorne VS, Neal CL, Sanghera S, Xu J, Yang J, Guo H, Steeg PS, Yu D. Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation. Cancer Res. 2009;69:9163-8.