Effect of Ethanol Extract of the Fruiting Bodies of Pleurotus Ostreatus on Serum Lipid Profile and Atherogenic Indices of HS-HFD-STZ Induced Diabetic Rats
Asian Journal of Research in Biochemistry,
The effect of ethanol extract of the fruiting bodies of Pleurotus ostreatus on serum lipid profile and atherogenic indices of high sucrose high fat diet streptozotocin (HS-HFD-STZ) induced diabetic rats was determined by standard methods. All the groups were fed high sucrose-high fat diet except the normal group. The Metformin HCl and ethanol extract was given once daily by gavage to the reference and experimental groups respectively at doses of 150mg/Kg b.w., 50mg/Kg b.w, 150mg/Kg b.w. and 300mg/Kg b.w. respectively while the normal control received saline solution. The HDL-cholesterol level was higher than the value of the disease group after 6 weeks of administration of extract at 300mg/kg and after 9 weeks administration of extract at 150mg/kg. HDL cholesterol concentration increased by 22.2% after 6 weeks of extract administration at 300mg/kg and by 16.7% and 28.3% respectively after 9 weeks of extract administration at 150mg/kg and 50mg/kg respectively, indicating that the POE extract has the capacity to reduce cardiovascular diseases. At all the doses of extract administered for treatment at 3 weeks, 6 weeks and 9 weeks intervals, there was dose and time dependent lowering of LDL: HDL ratio even below the recommended risk limit of ≤ 2.5 compared to the test control with value above 2.5. After 3 weeks of treatment with extract at administration concentration level of 150mg/kg, atherogenic indices were lowered and extract levels of 150mg/kg and 300mg/kg reduced atherogenic index value after 6 weeks of administration while after 9 weeks of treatment, extract at 150mg/kg concentration reduced atherogenic indices. The atherogenic indices of the diabetic animals under treatment were dose-and time dependently reduced by POE treatment as observed in this study.These results suggest a possible use of the extracts in the management of hyperlipidemic conditions, hypertension and associated complications.
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Martirosyan DM, Miroshnichenko LA, Kulokawa SN, Pogojeva AV, Zoloedov VI. Amaraanth oil application for heart disease and hypertension. Lipids in Health and Disease, 2007;6:1.
Thomas GS. President’s message: The global burden of cardiovascular disease. J Nucl Cardiol. 2007;14:621-662
Sang CJ, Yong TJ, Byung KY, Rezuanul I, Sunder RK, Gerald P, Kai YC, Chi HS,. White button mushroom (Agarieus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholestrolemic rats. Nutr Res 2009; 30:49-56.
Libby P. Current concepts of pathogenesis of the acute coronary syndromes. Circulation. 2001;104:365-372
Zicha T, Kunes J, Devynck MA. Abnormalities of membrane function and lipid metabolism in hypertansim: a review, American Journal of Hypertension, 1999; 12(3):315-331.
Hodel C. Myopathy and rhabdomyolysis with lipid-lowering therapy on progression of coronary atherosclerosis. 2002;JAMA 291:159-168
Arwa MTAl Nahdi, Annie John, Haider Raza: Elucidation of molecular mechanisms of streptozotocin-Induced oxidative stress, Apoptosis and Mitochondrial dysfunction in Rin-5f Pancreatic B-cells. Oxidative Medicine and cellular longevity. 2017;15
Mark G. Papich : Streptozocin Saunders Handbook of Veterinary drugs. Fourth edition, 2016
Kuo M. Pleurotus ostreatus: The oyster mushroom. Retrieved from the mushroom expert. Come web site; 2005.
Stamet P. “Chapter 21: Growth parameters for gourmet and medicinal mushroom species” growing gourmet and medicinal mushroom = Shokuyo oyobi yakuyo Kinoko no sabia (3rd ed.) Berkeley, California, USA: Ten speed press. 2000; 308-315.
Hall, Ian, R. . “Growing mushroom:L the commercial reality” (PDF). Lifestyle farmer. Auckland, New Zealand: Rural press: 2010;42-45.
Retrieved 26, January 2012.
Akpaja EO, Isikhuemhen OS, Okhuoya JA. Ethnomycology and usage of edible and medicinal mushrooms among the Igbo people of Nigeria. International Journal of Medicinal Mushroom 2003;313-319.
Beltran-Garcia, Miguel. J. Estarron – Espinosa, Mirna; Ogura, Tetsuya: “Volatile compounds secreted by the Oyster mushroom (Pleurotus ostreatus) and their antibacterial activities” Journal of Agricultural and food chemistry. 1997; 45(10): 4049.
Alarcon-Aguila J, Arancibia S, – Avila P, Fuentes O, Zamorano – Ponce E, Hernandex M. production and purification of statins from pleurotus ostreatus (Basidiomycetes) strains. Z Naturforsch C., 2003;58:62-64
Alam N, Yoon KN, Lee KR, Shin PG, Cheong JC, Yoo YB, Shim MJ, Lee MW, Lee UY, Lee TS.. Antioxidant activities and Tyrosinase inhibitory effects of different extracts from pleurotus ostreatus fruiting bodies. Mycobiology; 2010 38:295-301.
Maria EV, Talia O’ctavio P. Edible Mushrooms: Improving Human Health and Promoting Quality life. International Journal of Microbiology. 2014;2015 :14 .
Ruisheng Song: Mechanism of Metformin: A table of two sites. Diabetes care 2016; 39(2):187-189.
Okoroh PN, Uwakwe AA, Monago-Ighorodje CC, Onuoha SC, Ukegbu C.Y., Chukwuka CO. Antihyperglycemic effect of ethanol extract of fruiting bodies of organically cultivated Pleurotus ostreatus in high sucrose high fat diet streptozotocin induced diabetes in rats (In press); 2021.
Friedewald WT, Levy RI, Friedrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical chemistry. 1972; 18(6), 499-502.
Brunzell JA, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum JL. Lipoprotein management in patients with cardio metabolic risk. Consensus conference report from the American college of cardiology foundation. Journal of American college of cardiology, 2008;51(15):1512-1524.
Ikewuchi JC, Ikewuchi CC. Alteration of plasma lipid profile and atherogenic indices of cholesterol loaded rats by Tridax procumbens Linn: Implications for the management of obesity and cardiovascular diseases.Biokemistri; 2009;21(2):95-99.
Hu SH, Liang ZC, Chia YC, Lien JL, Chen KS, Lee MY, Wang JC. Antihyperlipidemic and antioxidant effects of extracts from pleurotus citrinopileatus. Journal of Agriculture and Food Chemistry. 2006; 54(6):2103-10.
Bindhu, Ravi, R. Emilin Renitta, M. Lak shim Prabha, Reya Issac & Shanti Naidu Evaluation of antidiabetic potential of oyster mushroom (Pleurotus ostreatus) in alloxan – induced diabetic mice. 2012; 101-109.
Ademuyiwa O, Ugbaja, Idumebos F, Adebawo O. Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure and disease, 2005;4:19.
Brunzell JA, Davidson M, Furberg CD, Goldberg RB., Howard BV. Stein, Witztum JL. Lipoprotein management in patients with cardio metabolic risk. Consensus conference report from the American college of cardiology foundation. Journal of American college of cardiology, 2008; 51(15):1512-1524.
Krauss RM, Blanche PJ, Rawlings RS, Fernstrom HS, Williams PT. Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia, American journal of clinical nutrition, 2006; 83(6):1025-1031.
Hossain S, Hashimoto M, Choudhury EK, Alam N, Hussain S, Hasan M, Choudhury SK, Mahmud I. Diatery mushroom (pleurotus ostreatus) amehorates atherogenic lipid in hypercholesterolaemic rats. Clinical and Experimental Pharmacology and Physiology. 2003; 30:470-475.
Rang HP, Dale MM, Ritter, JM, Moore P. K. Pharmacology, 5th edition. New Delhi. India. Elsevier 2005;359-87.
Usoro CAD, adikwuru CC, Usoro IN, Nsonwu AC. Lipid profile of postmenopausal women in calabar, Nigeria. Pakistan Journal of Nutrition, 2006;5(1):79-82.
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