Therapeutic Potential of Orally Administered Aqueous Seed Extract of Garcinia kola on Experimental Colitis Induced by Acetic Acid Colitis in Wistar Rats
A. Perede *
Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
O. G. Aviowro
Department of Medical Laboratory Science, Delta State University of Nigeria, Nigeria.
M. S. Abubakar
Department of Pathology Faculty of Veternary Medicine, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
S. M. Sahabi
Department of Morbid Anatomy and Forensic Medicine, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
I. Igbinosa
Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
S. M. Gamde
Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
U. Abubakar
Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
M. N. Chukwu
Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
M. Bello
Department of Chemical Pathology, Medical Laboratory Science, Specialist Hospital Sokoto, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Erosive colitis is a common disorder of the gastrointestinal tract with unknown cause, characterized by recurrent erosion of the colonic mucosal lining.
The pathogenesis likely involves genetic, environmental, and immunologic factors.
Aim: This study investigated the therapeutic effects of Garcinia kola (GK) on acetic acid-induced erosive colitis in adult male Wistar rats. Erosive colitis (EC) was induced in male Wistar rats by intra-rectal administration of 2 ml of 4 % acetic acid at 8 cm proximal to the anus for 30 seconds.
Methodology: Thirty-six animals were divided into six groups (n=6), negative control (no erosion, no GK); positive control (erosive colitis without treatment of GK extract); treated with 100, 200, 400mg/kg GK, standard treatment group (Prednisolone) for 14 days.
Results: Garcinia kola significantly improved Erosive colitis-induced reduction in mean stool consistency and mean macroscopic erosion score (P< 0.05). Injection of GK also significantly reduced the mean microscopic erosion score when compared to untreated EC control (P < 0.01). GK reduced the colonic mucosa injury of the Wistar rat.
Conclusion: Results of this study provide scientific evidence that lends credence to the use of aqueous seed extract of Garcinia kola in folklore medicine in the management of colitis erosion.
Keywords: Erosive colitis, Garcinia Kola, wistar rats