https://journalajrb.com/index.php/AJRB <p style="text-align: justify;"><strong>Asian Journal of Research in Biochemistry</strong> <strong>(ISSN: 2582-0516) </strong>aims to publish high quality papers (<a href="https://journalajrb.com/index.php/AJRB/general-guideline-for-authors">Click here for Types of paper</a>) in the field of Biochemistry. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> <p style="text-align: justify;"><strong>NAAS Score: 4.90 (2026)</strong></p> Asian Journal of Research in Biochemistry en-US Asian Journal of Research in Biochemistry 2582-0516 https://journalajrb.com/index.php/AJRB/article/view/507 <p><strong>Introduction</strong>: <em>Diabetes mellitus</em>, a metabolism disorder symptomized by high concentration of fasting blood glucose, poses major health challenge.</p> <p><strong>Aims:</strong> This research aimed at assessing antihyperglycemic potentials of n-hexane-partitioned (NHF), n-butanol-partitioned (NBF), ethyl acetate-partitioned (ETHF) and residual-partitioned fractions of <em>Cola acuminata </em>seed in streptozotocin-induced diabetic rats. Effects of these solvent-partitioned fractions were assessed on fasting blood glucose (FBS), serum insulin (SI) and hepatic glycogen (HG) concentration. Also, on activities of hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PDH), glucose-6-phospatase (G6Pase), fructose-1,6-bisphosphatase (F16BPase) and glycogen phosphorylase GPase).</p> <p><strong>Study design: </strong>Experimental design was completely randomized design and analysis of variance was used to process data with the aid of GraphPad Prism version 6.0.</p> <p><strong>Methodology: </strong>35 male, non-diabetic albino rats (weights between 120g – 150g) were randomly divided into 7 seven groups. Rats were induced with diabetes using streptozotocin except control group. Diabetic groups were administered distilled water, metformin, NHF, ETHF, NBF and residual-partitioned fraction (RF) of <em>Cola acuminata </em>seed respectively. Effects of these treatments were assessed on FBS, SI and HG concentrations of streptozotocin-induced diabetic rats after 15-day experimental period. Also, activities of HK, G6PDH, G6Pase, F16BPase and GPase were determined.</p> <p><strong>Results: </strong>NHF, ETHF, NBF and RF of <em>Cola acuminata </em>seed significantly alleviate <em>(P &lt; .05)</em> increased FBS concentration (from 30.73± 0.52 to 4.73± 0.34 mmol/L) and activities of G6Pase, F16Bpase and GPase (from 13.05 to 7.56; 13.72 to 9.09 and 8.96 to 3.33 U/L/mg protein respectively) while decreased concentration of SI and HG; activities of hepatic HK, G6PDH were notably increased <em>(P &lt; .05) </em>(from 1.57 to 3.20 mg/ml; 35.42 to 73.74 mg/dl; 0.64 to 1.42 mmol/min/mg protein; 1.51 to 2.26 U/L/mg protein)<em>. </em> </p> <p><strong>Conclusion: </strong>The study concluded that these solvent-partitioned fractions of <em>Cola acuminata </em>seed shows modulatory potentials on some glucose-metabolizing parameters via inhibition and stimulation of their activities and concentration.</p> A. O. Ogunsowo B. O. Olorundare E. F. Odeyemi C. O. Akinola P. O. Orimoloye A. O. Ajewole I. T. Famaye A. T. Adewuyi A. M. Paul E. A. Balogun Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2026-07-29 2026-07-29 16 5 1 15 10.9734/ajrb/2026/v16i5507