Asian Journal of Research in Biochemistry <p style="text-align: justify;"><strong>Asian Journal of Research in Biochemistry&nbsp;(ISSN: 2582-0516)</strong>&nbsp;aims to publish high quality papers (<a href="/index.php/AJRB/general-guideline-for-authors">Click here for Types of paper</a>) in the field of Biochemistry. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Asian Journal of Research in Biochemistry en-US Asian Journal of Research in Biochemistry 2582-0516 Alstonia boonei Leaf Mitigated Deleterious Effects of Experimental Type-II-Diabetes-Mellitus against Pancreatic and Neurocognitive Functions <p>The search for prompt, less toxic and economically affordable medical therapy has facilitated the increased investigation into the therapeutic potentials and applications of plants samples against common tropical ailments. This study was designed to investigate the reported link between experimental type II diabetes mellitus (T2DM) and neurocognitive decline and the justification for the use <em>Alstonia boonei </em>leaf in similar treatments. Experimental T2DM were treated with 100, 1000 and 1600 mg/kg BWT of the <em>Alstonia boonei </em>leaf and glibenclamide (100 mg/kg BWT). Biochemical analyses were used to determine effects on the pancreatic and neuronal indices of tissues functions; oxidative stress; excitation; and inflammation; blood glucose and insulin concentrations. The study revealed that T2DM and <em>Alstonia boonei </em>leaf affected the activity of tyrosine hydroxylase which is the regulating enzyme for the biosynthesis of dopamine. The oxidative and inflammatory stress exacerbated by T2DM was mitigated by a significant reduction of TNF-α and an increase of GSH, NP-SH, GPx, SOD and GST levels. <em>Alstonia boonei </em>leaf reversed the insulin resistance by the cells, with effective transduction of insulin signal and a corresponding reduction of circulating glucose. <em>Alstonia boonei </em>leaf demonstrated hypoglycaemic effect, and mitigated the neurodegeneration that ensued from the diabetic induction.</p> Violet Olubunmi Falusi Sunday Oluwayomi Bamidele Imoukhuede Gideon Oludare Oladipo ##submission.copyrightStatement## 2021-03-02 2021-03-02 19 35 10.9734/ajrb/2021/v8i230176 Recent Studies on the Therapeutic and Prophylactic Effect of Some Agents on Experimental Induced Parkinson Disease Models Review <p>Neurodegeneration include disease of the central nervous system (CNS) such as Parkinson’s disease (PD). The sign of this disease include destruction of dopaminergic neuronal cells. Main causes of this disease are unknown, but several studies reported polygenic causes. These include free radicals, malfunction of mitochondria, protein oxidation and DNA denaturation. Several reports implicated the involvement of oxygen species and stresses cause by over accumulation of reactive oxygen species in the contribution to the cascade that resulted in diminishing of dopamine cells destruction in this disease. Generally, natural defensive substances such as bio-cartelized (proteineous and non proteineous) from natural or synthetic sources played a unique role in protecting the susceptible neuronal cells from the adverse effects of the reactive oxygen species. In most cases antioxidant enzyme production by the body system diminished with advance age. Hence, treatment with antioxidant potential agent or administration of antioxidant substance with the common drugs used in the treatment of PD may yield positive result in protecting neurons from degenerative changes caused by reactive oxygen species. Recent studies on the therapeutic and prophylactic effect of some agents on experimental induced PD summarized in this review paper.</p> I. M. Hassan A. M. Abdullahi ##submission.copyrightStatement## 2021-02-23 2021-02-23 1 18 10.9734/ajrb/2021/v8i230175