Asian Journal of Research in Biochemistry <p style="text-align: justify;"><strong>Asian Journal of Research in Biochemistry</strong>&nbsp;<strong>(ISSN: 2582-0516)&nbsp;</strong>aims to publish high quality papers (<a href="/index.php/AJRB/general-guideline-for-authors">Click here for Types of paper</a>) in the field of Biochemistry. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> <p style="text-align: justify;">This is an open-access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.</p> en-US (Asian Journal of Research in Biochemistry) (Asian Journal of Research in Biochemistry) Mon, 28 Nov 2022 11:15:07 +0000 OJS 60 Phytochemical Profiling and GC-MS Analysis of the Methanol Extract of Anthocleista grandiflora Wood Bark <p>The plant, <em>Anthocleista grandiflora</em> is a member of the family Gentianaceae and commonly known as the “forest fever tree” used traditionally for the treatment of various ailments. Its methanol bark extract was subjected to preliminary phytochemical analysis using standard methods and the presence of bioactive compounds was determined using Gas chromatography mass spectroscopy (GC-MS). Results showed the presence of flavonoids in high amount, saponins and cardiac glycosides in moderate amount while tannins, phenols, terpenoids and steroids were present in low amounts. Test for alkaloids, glycosides, anthroquinones, pholobatannins and anthrocyannins showed that they were however absent. GC-MS analysis showed plenty bioactive compounds in which Hexadecanoic acid, methyl ester (45%) and 9-Octadecenoic acid (Z)-, methyl ester (43%) were most prevalent. These findings supports its current use by some locals to treat stomach ulcer and further portrays it as having great potential in the treatment of myriads of diseases.</p> Haruna G. Sunday, Abdullahi H. Sadiya, Ashikaa B. Ande, Ejiogu C. Ikedi, Madu Hauwa ##submission.copyrightStatement## Sat, 26 Nov 2022 00:00:00 +0000 Crinum glaucum Bulb Extract Improves the Lipid Profile of Endotoxin-Induced Wistar Rats <p><strong>Background and Objective:</strong> Medicinal plants are widely known as sources of potential that are used in traditional medicine. The effect of C<em>rinum glaucum </em>(<em>C. glaucum</em>) aqueous extract on the lipid profile of endotoxin-induced rats was evaluated.</p> <p><strong>Methodology</strong><strong>:</strong> Fifty Wistar rats (male and female) were divided randomly into five groups (n = 5). Group 1 is the control group. Group 2 was administered <em>C. glaucum </em>aqueous extract (1000 mg/kg body weight). Group 3 was endotoxin-induced with 1 ml/kg body weight single dose of lipopolysaccharide (LPS) for 4 hours. Group 4 was given LPS (4 hours) and treated with <em>C. glaucum </em>aqueous extract. Group 5 was administered <em>C. glaucum</em> aqueous extract, LPS, and <em>C. glaucum</em> aqueous extract. At the end of administration, blood and organs (brain, heart, lungs, liver, and kidney) were harvested for the lipid profile (triglyceride, cholesterol, and phospholipid) assay analysis using a spectrophotometric method.</p> <p><strong>Results: </strong>The reduction of cholesterol, triglyceride, and phospholipid concentrations is the hallmark of endotoxin, as revealed in this study. While <em>C. glaucum</em> administration significantly (p&lt;0.05) reduced cholesterol concentrations, there was an up- or down-regulation of triglyceride and phospholipid concentrations in the male compartments compared to the control. A similar trend was observed in the female compartment. Data also revealed that while LPS causes a reduction in lipid profiles, the administration of <em>C. glaucum</em> reverses the effect.</p> <p><strong>Conclusion:</strong> The findings of the research suggest that <em>C. glaucum</em> has an ameliorative and therapeutic effect in improving lipid dysfunctions.</p> Olabisi O. Ogunrinola, Rahmon I. Kanmodi, Gideon A. Adeyemo, Oluwaseyi A. Ogunrinola, Kehinde O. Olatunji, Aleem O. Fayemi, Amaka J. Sunday, Oluwatosin B. Adu, Babajide O. Elemo ##submission.copyrightStatement## Wed, 30 Nov 2022 00:00:00 +0000