Asian Journal of Research in Biochemistry https://journalajrb.com/index.php/AJRB <p style="text-align: justify;"><strong>Asian Journal of Research in Biochemistry&nbsp;(ISSN: 2582-0516)</strong>&nbsp;aims to publish high quality papers (<a href="/index.php/AJRB/general-guideline-for-authors">Click here for Types of paper</a>) in the field of Biochemistry. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> en-US contact@journalajrb.com (Asian Journal of Research in Biochemistry) contact@journalajrb.com (Asian Journal of Research in Biochemistry) Sat, 18 Jul 2020 10:40:50 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Study of the Potential Role of Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels in the Diagnosis and Prognosis of Breast Cancer in Egyptian Females "A Case-Control Study" https://journalajrb.com/index.php/AJRB/article/view/30128 <p><strong>Background: </strong>Breast cancer (BC) is the most common cause of malignancy in females all over the world. Continuous scientific research for the discovery of new markers helping is a cornerstone for early disease detection and proper management.</p> <p><strong>Aim of the Study: </strong>This study aimed to evaluate the role of Neutrophil gelatinase-associated lipocalin (NGAL) as prognostic markers for breast cancer in an Egyptian female population.</p> <p><strong>Patients and Methods: </strong>120 BC patients and 30 healthy controls were the subjects of the study; serum NGAL levels were investigated and correlated with the clinicopathologic characteristics of the BC patients.</p> <p><strong>Results: </strong>Our study showed that NGAL was significantly different between healthy controls and BC patients, and&nbsp; it revealed a gradual increase with disease severity.</p> <p><strong>Conclusion: </strong>Our findings suggested that NGAL could be diagnostic marker for early case detection, and was shown to be associated with breast cancer prognosis, supporting its role as prognostic biomarker.</p> F. Z. Mohammed, Lamis Gamal, Mohamed Farouk Mosa, I. M. El- deen ##submission.copyrightStatement## https://journalajrb.com/index.php/AJRB/article/view/30128 Sat, 18 Jul 2020 00:00:00 +0000 Proximate, Antinutrient and Mineral Contents of Aframomum danielli (Ataiko) Seed https://journalajrb.com/index.php/AJRB/article/view/30129 <p><strong>Background: </strong>Plant seeds are rich in nutrients and antinutrients which interfere with bioavailability of minerals.</p> <p><strong>Objective: </strong>This research was aimed at evaluating the proximate, anti-nutrients and minerals compositions and estimation of relative mineral bioavailability of <em>Aframomum danielli</em> seed (Ataiko).</p> <p><strong>Methods: </strong>Proximate composition was assessed by AOAC methods, minerals by atomic absorption spectrophotometry and anti-nutrients by titrimetric methods.</p> <p><strong>Results: </strong>Proximate compositions in percentage revealed carbohydrate with (51.95±0.15), crude fibre (16.00±0.10) and fat (2.35±0.15) was least. Caloric value (kcal 100 g) was 286.55±2.75 Phytate (1.98±0.03%) was higher than oxalate (0.06±0.00%). Major mineral percentage included phosphorus (7401.43 ± 318.24) and sulphur (1926.58 ± 21.49), minor minerals were in trace amounts. Molar ratios of phytate: Fe, Zn and Ca and oxalate:Ca were above their critical values.</p> <p><strong>Conclusion: </strong><em>A. daneilli seed</em> is rich in nutrients, has high caloric value. High intake could lead to micronutrient malnutrition.</p> Peters Dikioye Emmanuel, Kojo, Sarah ##submission.copyrightStatement## https://journalajrb.com/index.php/AJRB/article/view/30129 Wed, 29 Jul 2020 00:00:00 +0000 Essential Oil Compositions of Aframomum danielli Seed (Ataiko) https://journalajrb.com/index.php/AJRB/article/view/30130 <p><strong>Background:</strong> Differentiation in oil quality and the volatile component of essential oils (EOs) is associated with climatic conditions, the geographical location of collection sites and other ecological and genetic factors defining its chemotypes.</p> <p><strong>Objective:</strong> Hence this study was aimed at characterizing volatile constituents of <em>Aframomum danielli </em>seed collected in Choba, Port Harcourt in Rivers State, South-South region of Nigeria.</p> <p><strong>Methods:</strong> Essential oils (EOs) were analyzed using gas chromatography–flame ionization detector (GC-FID).</p> <p><strong>Results:</strong> A total of forty-two EO (99.96%) constituents were identified, monoterpenes were 32 (99.93%) and sesquiterpenes: 10 (0.03%) No oxygenated sesquiterpenes were detected. Oxygenated monoterpene was higher consisting of 18 EO compounds; 66.94% while monoterpene hydrocarbons comprised of 14 EO compounds; 32.99%. Chemical constituents in the EO include: 1,8- cineole (50.95%), β-pinene (11.79%) –terpineol (9.15%), γ –terpinene (7.45%), Sabinene (6.03%), - pinene (3.41%), α –terpinenly acetate (3.38%), terpinene-4-of(2.44%) and α-thujene (2.11%).</p> <p><strong>Conclusion: </strong><em>Aframomum danielli </em>from this geographical location could serve as a rich source of 1,8- cineole.</p> Peters Dikioye Emmanuel, Blessing Minaopunye Onyegeme- Okerenta, Kojo, Sarah ##submission.copyrightStatement## https://journalajrb.com/index.php/AJRB/article/view/30130 Thu, 30 Jul 2020 00:00:00 +0000 In vivo Antioxidant Effects of Coconut (Cocos nucifera) Water Extract in Wistar Albino Rats https://journalajrb.com/index.php/AJRB/article/view/30131 <p><strong>Aim:</strong> The present study was designed to investigate the invivo antioxidant effects of coconut (<em>Cocos nucifera</em>) water extract in wistar albino rats.</p> <p><strong>Methodology:</strong> Thirty (30) male wistar albino rats of mean weight 128 g were used for the study. The animals for the study were grouped into five (5) of six (6) rats each. Group 1 served as the normal control group that received feed and water only while groups 2, 3, 4, and 5 served as the test groups that were orally given 10 ml, 20 ml, 30 ml, and 40 ml of the coconut water extract for 28 days. The rats were sacrificed after 28 days and the blood samples were collected for biochemical analysis.&nbsp;</p> <p><strong>Results:</strong> From the result obtained there is a significant increase (p&lt; 0.05) between the normal control group (group 1) and the test group (group 2) that received 20 ml of the coconut water extract for MDA. There is a significant increase (p&lt; 0.05) between the normal control group (group 1) and the test groups (groups 2 and 5) that received 10 ml and 50 ml of the coconut water extract for SOD. Also, there is a significant increase (p&lt; 0.05) between the normal control group (group 1) and the test groups (groups 2, 3 and 4) that received 20 ml, 30 ml and 40 ml of the coconut water extract for Catalase. For GSH and Vitamin C, there is a significant increase (p&lt; 0.05) between the normal control group (group 1) and the test groups (groups 2, 3, 4 and 5) that were orally given 10 ml, 20 ml, 30 ml and 40 ml of the coconut water extract.</p> <p><strong>Conclusion: </strong>The present investigation showed that the coconut water extract increased antioxidant properties in wistar albino rats and may also be used pharmacologically in the treatment of diseases implicated by free radicals.</p> O. J. Mba, U. I. Edward, O. A. Aja, I. E. Atiaetuk, M. K. Ndukwe ##submission.copyrightStatement## https://journalajrb.com/index.php/AJRB/article/view/30131 Sat, 01 Aug 2020 00:00:00 +0000