L.V. Spirina is the author of more than 130 published works, including the monograph "Squamous cell carcinoma of the head and neck: the molecular basis of pathogenesis."

The main scientific interests are molecular markers of development and progression of malignant neoplasms. The main subject of scientific work is the conduct of fundamental research on the role of proteolytic enzymes in the development of malignant neoplasms. Spirina L.V. has received important results both for understanding the patterns of tumor growth, and in practice for the formation of high-risk groups and evaluating the prognosis of malignant tumors. Currently she develops molecular approaches for the optimal choice of targeted drugs in patients with disseminated kidney cancer